9/22/2023 0 Comments System shock 2 brain of the many![]() We show that SARS-CoV-2 is widely distributed, predominantly among patients who died with severe COVID-19, and that virus replication is present in multiple respiratory and non-respiratory tissues, including the brain, early in infection. Here we carried out complete autopsies on 44 patients who died with COVID-19, with extensive sampling of the central nervous system in 11 of these patients, to map and quantify the distribution, replication and cell-type specificity of SARS-CoV-2 across the human body, including the brain, from acute infection to more than seven months following symptom onset. However, the burden of infection outside the respiratory tract and time to viral clearance are not well characterized, particularly in the brain 3, 6, 7, 8, 9, 10, 11, 12, 13, 14. Nature volume 612, pages 758–763 ( 2022) Cite this articleĬoronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction 1, 2, 3 during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with some patients experiencing prolonged symptoms, termed post-acute sequelae of SARS-CoV-2 (refs. SARS-CoV-2 infection and persistence in the human body and brain at autopsy
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